Version 5.4
Mus musculus Protein: Itgal
Summary
InnateDB Protein IDBP-400203.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Itgal
Protein Name integrin alpha L
Synonyms (p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21;
Species Mus musculus
Ensembl Protein ENSMUSP00000113396
InnateDB Gene IDBG-210127 (Itgal)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0007159 leukocyte cell-cell adhesion
GO:0007166 cell surface receptor signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0022407 regulation of cell-cell adhesion
GO:0022409 positive regulation of cell-cell adhesion
GO:0042102 positive regulation of T cell proliferation
GO:0050798 activated T cell proliferation
GO:0050850 positive regulation of calcium-mediated signaling
Cellular Component
GO:0001772 immunological synapse
GO:0005911 cell-cell junction
GO:0008305 integrin complex
GO:0009897 external side of plasma membrane
Protein Structure and Domains
PDB ID MGI:96606
InterPro IPR000413 Integrin alpha chain
IPR002035 von Willebrand factor, type A
IPR013517 FG-GAP repeat
IPR013519 Integrin alpha beta-propellor
IPR013649 Integrin alpha-2
PFAM PF00092
PF01839
PF14312
PF08441
PRINTS PR01185
PIRSF
SMART SM00327
SM00191
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL D3Z627
UniProt Splice Variant
Entrez Gene 16408
UniGene Mm.1618
RefSeq
MGI ID
MGI Symbol Itgal
OMIM
CCDS
HPRD
IMGT
EMBL AC133494
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca