InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Itgal

Summary

InnateDB Gene

IDBG-210127.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Itgal

Gene Name

integrin alpha L

Synonyms

(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030830

Encoded Proteins

IDBP-269029

integrin alpha L

IDBP-400197

integrin alpha L

IDBP-400203

integrin alpha L

IDBP-400201

integrin alpha L

IDBP-621600

integrin alpha L

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000005844:
ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:127296260-127335137

Strand

Forward strand

Band

Transcripts

ENSMUST00000106306	ENSMUSP00000101913
ENSMUST00000117762	ENSMUSP00000113946
ENSMUST00000120857	ENSMUSP00000113396
ENSMUST00000118405	ENSMUSP00000112591
ENSMUST00000170971	ENSMUSP00000131847

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0032403	protein complex binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0002291	T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
GO:0007157	heterophilic cell-cell adhesion
GO:0007159	leukocyte cell-cell adhesion
GO:0007166	cell surface receptor signaling pathway
GO:0007229	integrin-mediated signaling pathway
GO:0016337	single organismal cell-cell adhesion
GO:0022407	regulation of cell-cell adhesion
GO:0022409	positive regulation of cell-cell adhesion
GO:0042102	positive regulation of T cell proliferation
GO:0050798	activated T cell proliferation
GO:0050850	positive regulation of calcium-mediated signaling

Cellular Component

GO:0001772	immunological synapse
GO:0005911	cell-cell junction
GO:0008305	integrin complex
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome