InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Scn5a

Summary

InnateDB Protein

IDBP-400261.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Scn5a

Protein Name

sodium channel, voltage-gated, type V, alpha

Synonyms

mH1; Nav1.5; Nav1.5c; SkM1; SkM2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000113272

InnateDB Gene

IDBG-204746 (Scn5a)

Protein Structure

UniProt Annotation

Function

This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na(+) channel isoform. Channel inactivation is regulated by intracellular calcium levels (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed in the myocardium. {ECO:0000269PubMed:11834499}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005248	voltage-gated sodium channel activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0086006	voltage-gated sodium channel activity involved in cardiac muscle cell action potential
GO:0086063	voltage-gated sodium channel activity involved in regulation of SA node cell action potential
GO:0097110	scaffold protein binding

Biological Process

GO:0003231	cardiac ventricle development
GO:0006811	ion transport
GO:0006814	sodium ion transport
GO:0014070	response to organic cyclic compound
GO:0019228	neuronal action potential
GO:0034765	regulation of ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0055085	transmembrane transport
GO:0071277	cellular response to calcium ion
GO:0086004	regulation of cardiac muscle cell contraction
GO:0086012	membrane depolarization during cardiac muscle cell action potential
GO:0086046	membrane depolarization involved in regulation of SA node cell action potential
GO:0086091	regulation of heart rate by cardiac conduction

Cellular Component

GO:0001518	voltage-gated sodium channel complex
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0014704	intercalated disc
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030315	T-tubule
GO:0034706	sodium channel complex

Protein Structure and Domains

PDB ID

MGI:98251

InterPro

IPR001696 Voltage gated sodium channel, alpha subunit
IPR005821 Ion transport domain
IPR008053 Voltage gated sodium channel, alpha-5 subunit
IPR010526 Sodium ion transport-associated
IPR013122 Polycystin cation channel, PKD1/PKD2
IPR024583 Domain of unknown function DUF3451

PFAM

PF00520
PF06512
PF08016
PF11933

PRINTS

PR00170
PR01666

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9JJV9