Version 5.4
Mus musculus Gene: Scn5a
Summary
InnateDB Gene IDBG-204746.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Scn5a
Gene Name sodium channel, voltage-gated, type V, alpha
Synonyms mH1; Nav1.5; Nav1.5c; SkM1; SkM2
Species Mus musculus
Ensembl Gene ENSMUSG00000032511
Encoded Proteins
IDBP-204748
sodium channel, voltage-gated, type V, alpha
IDBP-400260
sodium channel, voltage-gated, type V, alpha
IDBP-400261
sodium channel, voltage-gated, type V, alpha
IDBP-538909
sodium channel, voltage-gated, type V, alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 25368329
[Homo sapiens] SCN5A is a novel pathogen sensor that initiates anti-viral signalling and transcription through ADCY8 and ATF2.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000183873:
The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:119483408-119579016
Strand Reverse strand
Band F3
Transcripts
ENSMUST00000065196 ENSMUSP00000066228
ENSMUST00000117911 ENSMUSP00000112838
ENSMUST00000120420 ENSMUSP00000113272
ENSMUST00000138934 ENSMUSP00000118250
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005248 voltage-gated sodium channel activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential
GO:0086063 voltage-gated sodium channel activity involved in regulation of SA node cell action potential
GO:0097110 scaffold protein binding
Biological Process
GO:0003231 cardiac ventricle development
GO:0006811 ion transport
GO:0006814 sodium ion transport
GO:0014070 response to organic cyclic compound
GO:0019228 neuronal action potential
GO:0034765 regulation of ion transmembrane transport
GO:0035725 sodium ion transmembrane transport
GO:0055085 transmembrane transport
GO:0071277 cellular response to calcium ion
GO:0086004 regulation of cardiac muscle cell contraction
GO:0086012 membrane depolarization during cardiac muscle cell action potential
GO:0086046 membrane depolarization involved in regulation of SA node cell action potential
GO:0086091 regulation of heart rate by cardiac conduction
Cellular Component
GO:0001518 voltage-gated sodium channel complex
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0014704 intercalated disc
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030315 T-tubule
GO:0034706 sodium channel complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000183873
View Gene Order
ENSBTAG00000009155
Not yet available
Pathways
NETPATH
REACTOME
REACT_244931
Interaction between L1 and Ankyrins pathway
REACT_261444
Axon guidance pathway
REACT_219680
L1CAM interactions pathway
REACT_188576
Developmental Biology pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_22266
Interaction between L1 and Ankyrins pathway
REACT_22205
L1CAM interactions pathway
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9JJV9
TrEMBL D3YXW2 Q6EWG4
UniProt Splice Variant
Entrez Gene 20271
UniGene Mm.103584 Mm.490207
RefSeq NM_021544 XM_006511994 NM_001253860 XM_006511993 XM_006511995 XM_006511997
OMIM
CCDS CCDS52965 CCDS57715
HPRD
IMGT
MGI ID MGI:98251
MGI Symbol Scn5a
EMBL AC121922 AC171201 AJ271477 AJ623273 AK147254 AK147517
GenPept BAE27800 BAE27966 CAB70096 CAF25043
RNA Seq Atlas 20271

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca