Version 5.4
Mus musculus Protein: Insc
Summary
InnateDB Protein IDBP-400276.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Insc
Protein Name inscuteable homolog (Drosophila)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000112682
InnateDB Gene IDBG-207316 (Insc)
Protein Structure
UniProt Annotation
Function May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex. Involved in spindle orientation during mitosis it may regulate cell proliferation and differentiation in the developing nervous system. May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the squamous epithelium. {ECO:0000269PubMed:16094321, ECO:0000269PubMed:16301171}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:16094321, ECO:0000269PubMed:16301171}. Note=Localizes to the apical cortex of mitotic epidermal cells and to the apical side of neuronal progenitor cells.
Disease Associations
Tissue Specificity Expressed in brain, kidney, liver, testis and skin. {ECO:0000269PubMed:16094321, ECO:0000269PubMed:16301171}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0000132 establishment of mitotic spindle orientation
GO:0007399 nervous system development
GO:0060487 lung epithelial cell differentiation
Cellular Component
GO:0005737 cytoplasm
GO:0045177 apical part of cell
Protein Structure and Domains
PDB ID MGI:1917942
InterPro IPR000225 Armadillo
IPR016024 Armadillo-type fold
PFAM PF00514
PRINTS
PIRSF
SMART SM00185
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3HNM7
PhosphoSite PhosphoSite-Q3HNM7
TrEMBL G3UW77
UniProt Splice Variant
Entrez Gene 233752
UniGene Mm.83037
RefSeq XP_006507722
MGI ID 3RO3
MGI Symbol Insc
OMIM
CCDS CCDS40095
HPRD
IMGT
EMBL AC102792 AC110186 AK050143 BC139196 BC139197 BY236076 CH466531 DQ205645
GenPept AAI39197 AAI39198 ABA54267 BAC34091 EDL17080 EDL17081

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca