Version 5.4
Mus musculus Gene: Insc
Summary
InnateDB Gene IDBG-207316.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Insc
Gene Name inscuteable homolog (Drosophila)
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000048782
Encoded Proteins
IDBP-400276
inscuteable homolog (Drosophila)
IDBP-535260
inscuteable homolog (Drosophila)
IDBP-542368
inscuteable homolog (Drosophila)
IDBP-536224
inscuteable homolog (Drosophila)
IDBP-620242
inscuteable homolog (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000188487:
In Drosophila, neuroblasts divide asymmetrically into another neuroblast at the apical side and a smaller ganglion mother cell on the basal side. Cell polarization is precisely regulated by 2 apically localized multiprotein signaling complexes that are tethered by Inscuteable, which regulates their apical localization (Izaki et al., 2006 [PubMed 16458856]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:114743694-114850380
Strand Forward strand
Band F1
Transcripts
ENSMUST00000117543 ENSMUSP00000112682
ENSMUST00000161800 ENSMUSP00000125061
ENSMUST00000136645 ENSMUSP00000119459
ENSMUST00000139670
ENSMUST00000151464 ENSMUSP00000117296
ENSMUST00000136347
ENSMUST00000150991
ENSMUST00000169913 ENSMUSP00000129505
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0000132 establishment of mitotic spindle orientation
GO:0007399 nervous system development
GO:0060487 lung epithelial cell differentiation
Cellular Component
GO:0005737 cytoplasm
GO:0045177 apical part of cell
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000188487
View Gene Order
ENSBTAG00000032782
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.412387 Mm.83037
RefSeq NM_173767 XM_006507660 XM_006507661 XM_006507663 XM_006507664
OMIM
CCDS CCDS40095
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca