Version 5.4
Mus musculus Protein: Trafd1
Summary
InnateDB Protein IDBP-400293.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Trafd1
Protein Name TRAF type zinc finger domain containing 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000113910
InnateDB Gene IDBG-197203 (Trafd1)
Protein Structure
UniProt Annotation
Function Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3. {ECO:0000269PubMed:16221674, ECO:0000269PubMed:18849341}.
Subcellular Localization
Disease Associations
Tissue Specificity Expressed in skeletal muscle, brain, liver, kidney, spleen and bone marrow. Expression depends on STAT1. {ECO:0000269PubMed:16221674}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0034097 response to cytokine
GO:0045824 negative regulation of innate immune response
Cellular Component
GO:0005575 cellular_component
Protein Structure and Domains
PDB ID MGI:1923551
InterPro IPR001293 Zinc finger, TRAF-type
IPR008974 TRAF-like
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3UDK1
PhosphoSite PhosphoSite-Q3UDK1
TrEMBL D3Z5F4
UniProt Splice Variant
Entrez Gene 231712
UniGene Mm.482853
RefSeq NP_758479
MGI ID
MGI Symbol Trafd1
OMIM
CCDS CCDS51639
HPRD
IMGT
EMBL AC126938 AK150038 BC038396
GenPept AAH38396 BAE29260

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca