InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lepre1

Summary

InnateDB Protein

IDBP-400295.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lepre1

Protein Name

leprecan 1

Synonyms

2410024C15Rik; Gros1; P3H1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000112504

InnateDB Gene

IDBG-182649 (Lepre1)

Protein Structure

UniProt Annotation

Function

Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro- Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum {ECO:0000255PROSITE- ProRule:PRU10138}. Secreted, extracellular space, extracellular matrix {ECO:0000250}. Note=Secreted into the extracellular matrix as a chondroitin sulfate proteoglycan (CSPG).

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0016491	oxidoreductase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0019797	procollagen-proline 3-dioxygenase activity
GO:0031418	L-ascorbic acid binding

Biological Process

GO:0016049	cell growth
GO:0019511	peptidyl-proline hydroxylation
GO:0030199	collagen fibril organization
GO:0030278	regulation of ossification
GO:0032963	collagen metabolic process
GO:0055114	oxidation-reduction process