InnateDB Protein
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IDBP-400312.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ikzf4
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Protein Name
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IKAROS family zinc finger 4
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Synonyms
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A630026H08Rik; Eos; Zfpn1a4; Znfn1a4;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000113478
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InnateDB Gene
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IDBG-198041 (Ikzf4)
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Protein Structure
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Function |
DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. {ECO:0000269PubMed:10218586, ECO:0000269PubMed:17403896}.
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Subcellular Localization |
Nucleus.
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Disease Associations |
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Tissue Specificity |
Expressed mainly in the brain. Up-regulated in long term cultured astrocytes. Down-regulated during osteoclast differentiation. {ECO:0000269PubMed:10218586, ECO:0000269PubMed:17403896}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
|
Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
14 [view]
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Molecular Function |
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Biological Process |
GO:0006351
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transcription, DNA-templated
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GO:0045892
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negative regulation of transcription, DNA-templated
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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Cellular Component |
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PDB ID |
MGI:1343139
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InterPro |
IPR007087
Zinc finger, C2H2
IPR015880
Zinc finger, C2H2-like
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PFAM |
PF00096
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PRINTS |
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PIRSF |
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SMART |
SM00355
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TIGRFAMs |
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Modification |
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SwissProt |
Q8C208
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
22781
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UniGene |
Mm.488964
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RefSeq |
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MGI ID |
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MGI Symbol |
Ikzf4
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AB017615
AC117232
AK089522
AK170453
BC141286
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GenPept |
AAI41287
BAA36213
BAC40912
BAE41808
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