InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Shisa5

Summary

InnateDB Protein

IDBP-400319.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Shisa5

Protein Name

shisa homolog 5 (Xenopus laevis)

Synonyms

2310008D10Rik; 6430628I05Rik; mShisa5; Scotin;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000114078

InnateDB Gene

IDBG-201052 (Shisa5)

Protein Structure

UniProt Annotation

Function

Can induce apoptosis in a caspase-dependent manner and plays a role in p53/TP53-dependent apoptosis. {ECO:0000269PubMed:12135983}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:12135983}; Single-pass type I membrane protein {ECO:0000269PubMed:12135983}. Nucleus membrane {ECO:0000269PubMed:12135983}.

Disease Associations

Tissue Specificity

Spleen and thymus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0050699	WW domain binding

Biological Process

GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator

Cellular Component

GO:0005635	nuclear envelope
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane
GO:0031965	nuclear membrane