Version 5.4
Mus musculus Gene: Shisa5
Summary
InnateDB Gene IDBG-201052.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Shisa5
Gene Name shisa homolog 5 (Xenopus laevis)
Synonyms 2310008D10Rik; 6430628I05Rik; mShisa5; Scotin
Species Mus musculus
Ensembl Gene ENSMUSG00000025647
Encoded Proteins
IDBP-201054
shisa homolog 5 (Xenopus laevis)
IDBP-201056
shisa homolog 5 (Xenopus laevis)
IDBP-256811
shisa homolog 5 (Xenopus laevis)
IDBP-400318
shisa homolog 5 (Xenopus laevis)
IDBP-400319
shisa homolog 5 (Xenopus laevis)
IDBP-539971
shisa homolog 5 (Xenopus laevis)
IDBP-626883
shisa homolog 5 (Xenopus laevis)
IDBP-626887
shisa homolog 5 (Xenopus laevis)
IDBP-626888
shisa homolog 5 (Xenopus laevis)
IDBP-626889
shisa homolog 5 (Xenopus laevis)
IDBP-626890
shisa homolog 5 (Xenopus laevis)
IDBP-626891
shisa homolog 5 (Xenopus laevis)
IDBP-626892
shisa homolog 5 (Xenopus laevis)
IDBP-626893
shisa homolog 5 (Xenopus laevis)
IDBP-626894
shisa homolog 5 (Xenopus laevis)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164054:
This gene encodes a member of the shisa family. The encoded protein is localized to the endoplasmic reticulum, and together with p53 induces apoptosis in a caspase-dependent manner. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:109038565-109057724
Strand Forward strand
Band F2
Transcripts
ENSMUST00000026737 ENSMUSP00000026737
ENSMUST00000059097 ENSMUSP00000059025
ENSMUST00000112059 ENSMUSP00000107690
ENSMUST00000120218 ENSMUSP00000113967
ENSMUST00000120305 ENSMUSP00000114078
ENSMUST00000137282
ENSMUST00000127969 ENSMUSP00000119376
ENSMUST00000155541 ENSMUSP00000128175
ENSMUST00000154113 ENSMUSP00000127241
ENSMUST00000128976 ENSMUSP00000130946
ENSMUST00000135942 ENSMUSP00000130500
ENSMUST00000143754 ENSMUSP00000127418
ENSMUST00000124432 ENSMUSP00000130652
ENSMUST00000154184 ENSMUSP00000128901
ENSMUST00000151141 ENSMUSP00000126267
ENSMUST00000152771 ENSMUSP00000126317
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0050699 WW domain binding
Biological Process
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
Cellular Component
GO:0005635 nuclear envelope
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0031965 nuclear membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000164054
View Gene Order
ENSBTAG00000009183
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04115
p53 signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04115
p53 signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E9Q3X2 E9Q633 E9Q653
UniProt Splice Variant
Entrez Gene 66940
UniGene
RefSeq NM_001284332 NM_025858 NM_026381 XM_006512213 XM_006512214 XM_006512215 XM_006512216 XM_006512217 XM_006512218 XM_006512219 XM_006512220
OMIM
CCDS CCDS23543 CCDS40771 CCDS72309
HPRD
IMGT
MGI ID MGI:1915044
MGI Symbol Shisa5
EMBL AC140383
GenPept
RNA Seq Atlas 66940

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca