Version 5.4
Mus musculus Protein: Top3a
Summary
InnateDB Protein IDBP-400415.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Top3a
Protein Name topoisomerase (DNA) III alpha
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000113653
InnateDB Gene IDBG-181695 (Top3a)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003916 DNA topoisomerase activity
GO:0003917 DNA topoisomerase type I activity
Biological Process
GO:0006265 DNA topological change
Cellular Component
GO:0005694 chromosome
Protein Structure and Domains
PDB ID MGI:1197527
InterPro IPR000380 DNA topoisomerase, type IA
IPR003601 DNA topoisomerase, type IA, domain 2
IPR003602 DNA topoisomerase, type IA, DNA-binding
IPR006171 Toprim domain
IPR013497 DNA topoisomerase, type IA, central
IPR013498 DNA topoisomerase, type IA, zn finger
IPR023405 DNA topoisomerase, type IA, core domain
PFAM PF01751
PF13662
PF01131
PF01396
PRINTS PR00417
PIRSF
SMART SM00436
SM00437
SM00493
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL B0QZI1
UniProt Splice Variant
Entrez Gene 21975
UniGene Mm.477819
RefSeq
MGI ID
MGI Symbol Top3a
OMIM
CCDS
HPRD
IMGT
EMBL AL596215
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca