InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Syt2

Summary

InnateDB Protein

IDBP-400478.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Syt2

Protein Name

synaptotagmin II

Synonyms

mKIAA4194; R74640;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000112438

InnateDB Gene

IDBG-194117 (Syt2)

Protein Structure

UniProt Annotation

Function

May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.

Subcellular Localization

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass membrane protein. Cytoplasm. Note=Synaptic vesicles and chromaffin granules.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005544	calcium-dependent phospholipid binding

Biological Process

GO:0006810

transport

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030672	synaptic vesicle membrane
GO:0042584	chromaffin granule membrane
GO:0043231	intracellular membrane-bounded organelle