Mus musculus Protein: Gapdh | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-400490.4 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | Gapdh | ||||||||||||||||||
Protein Name | glyceraldehyde-3-phosphate dehydrogenase | ||||||||||||||||||
Synonyms | Gapd; | ||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||
Ensembl Protein | ENSMUSP00000113942 | ||||||||||||||||||
InnateDB Gene | IDBG-189466 (Gapdh) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3- phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S- nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. {ECO:0000269PubMed:23071094}. | ||||||||||||||||||
Subcellular Localization | Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Translocates to the nucleus following S-nitrosylation and interaction with SIAH1, which contains a nuclear localization signal. {ECO:0000250}. | ||||||||||||||||||
Disease Associations | |||||||||||||||||||
Tissue Specificity | |||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | MGI:95640 | ||||||||||||||||||
InterPro |
IPR006424
Glyceraldehyde-3-phosphate dehydrogenase, type I IPR020828 Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain IPR020829 Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family |
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PFAM |
PF00044
PF02800 |
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PRINTS |
PR00078
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PIRSF |
PIRSF000149
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SMART |
SM00846
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TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | |||||||||||||||||||
PhosphoSite | PhosphoSite-P16858 | ||||||||||||||||||
TrEMBL | S4R1W8 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 14433 | ||||||||||||||||||
UniGene | Mm.482927 | ||||||||||||||||||
RefSeq | NP_001276655 | ||||||||||||||||||
MGI ID | |||||||||||||||||||
MGI Symbol | Gapdh | ||||||||||||||||||
OMIM | |||||||||||||||||||
CCDS | |||||||||||||||||||
HPRD | |||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AC166162 AK002273 AK081405 AK140794 AK144690 AK146435 AK147738 AK147891 AK160399 AK160495 AK160753 AK164415 AK168217 AL662926 AY618199 AY618568 BC082592 BC083065 BC083079 BC083080 BC083149 BC085274 BC085275 BC085315 BC091768 BC092252 BC092264 BC092267 BC092294 BC093508 BC094037 BC095932 BC096440 BC096590 BC110311 BC145810 BC145812 CH466523 DQ403054 GU214026 M32599 | ||||||||||||||||||
GenPept | AAA37659 AAH82592 AAH83065 AAH83079 AAH83080 AAH83149 AAH85274 AAH85275 AAH85315 AAH91768 AAH92252 AAH92264 AAH92267 AAH92294 AAH93508 AAH94037 AAH95932 AAH96440 AAH96590 AAI10312 AAI45811 AAI45813 AAT40729 AAU89484 ABD77187 ADA57700 BAB21979 BAC38211 BAE24481 BAE26016 BAE27169 BAE28105 BAE28208 BAE35768 BAE35822 BAE35989 BAE37778 BAE40174 CAI25599 EDK99813 | ||||||||||||||||||