InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gapdh

Summary

InnateDB Gene

IDBG-189466.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gapdh

Gene Name

glyceraldehyde-3-phosphate dehydrogenase

Synonyms

Gapd

Species

Mus musculus

Ensembl Gene

ENSMUSG00000057666

Encoded Proteins

IDBP-189468

glyceraldehyde-3-phosphate dehydrogenase

IDBP-400491

glyceraldehyde-3-phosphate dehydrogenase

IDBP-400490

glyceraldehyde-3-phosphate dehydrogenase

IDBP-787629

glyceraldehyde-3-phosphate dehydrogenase

IDBP-787630

glyceraldehyde-3-phosphate dehydrogenase

IDBP-787632

glyceraldehyde-3-phosphate dehydrogenase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein was originally identified as a key glycolytic enzyme that converts D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Subsequent studies have assigned a variety of additional functions to the protein including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferrin receptor on the cell surface of macrophage. Alternative splicing results in multiple transcript variants. Many pseudogenes similar to this locus are found throughout the mouse genome. [provided by RefSeq, Jan 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:125161853-125166467

Strand

Reverse strand

Band

Transcripts

ENSMUST00000073605	ENSMUSP00000073289
ENSMUST00000118875	ENSMUSP00000113213
ENSMUST00000117757	ENSMUSP00000113942
ENSMUST00000147954
ENSMUST00000144205
ENSMUST00000144588
ENSMUST00000183272	ENSMUSP00000138508
ENSMUST00000182464
ENSMUST00000182115
ENSMUST00000182052	ENSMUSP00000138403
ENSMUST00000182277	ENSMUSP00000138295
ENSMUST00000182670

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.

Experimentally validated
Total	29 [view]
Protein-Protein	28 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004365	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0019899	enzyme binding
GO:0035605	peptidyl-cysteine S-nitrosylase activity
GO:0050661	NADP binding
GO:0051287	NAD binding

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0006006	glucose metabolic process
GO:0006096	glycolytic process
GO:0017148	negative regulation of translation
GO:0035606	peptidyl-cysteine S-trans-nitrosylation
GO:0050821	protein stabilization
GO:0051402	neuron apoptotic process
GO:0055114	oxidation-reduction process