InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Crtc3

Summary

InnateDB Protein

IDBP-400510.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Crtc3

Protein Name

CREB regulated transcription coactivator 3

Synonyms

2610312F20Rik; 6332415K15Rik; AI429792; BC011210; TORC3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000113540

InnateDB Gene

IDBG-195478 (Crtc3)

Protein Structure

UniProt Annotation

Function

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Appears to be mainly nuclear. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0008140	cAMP response element binding protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0032793	positive regulation of CREB transcription factor activity
GO:0043951	negative regulation of cAMP-mediated signaling
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050995	negative regulation of lipid catabolic process
GO:0051289	protein homotetramerization
GO:0097009	energy homeostasis