InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Isg20

Summary

InnateDB Protein

IDBP-400532.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Isg20

Protein Name

interferon-stimulated protein

Synonyms

1600023I01Rik; 2010107M23Rik; 20kDa; DnaQL; HEM45;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000113255

InnateDB Gene

IDBG-193515 (Isg20)

Protein Structure

UniProt Annotation

Function

Interferon-induced antiviral exoribonuclease that acts on single-stranded RNA and also has minor activity towards single- stranded DNA. Exhibits antiviral activity against RNA viruses in an exonuclease-dependent manner. May also play additional roles in the maturation of snRNAs and rRNAs, and in ribosome biogenesis (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Cytoplasm {ECO:0000250}. Nucleus, Cajal body {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000175	3'-5'-exoribonuclease activity
GO:0003676	nucleic acid binding
GO:0004527	exonuclease activity
GO:0008310	single-stranded DNA 3'-5' exodeoxyribonuclease activity
GO:0008859	exoribonuclease II activity
GO:0030619	U1 snRNA binding
GO:0030620	U2 snRNA binding
GO:0034511	U3 snoRNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000738	DNA catabolic process, exonucleolytic
GO:0006364	rRNA processing
GO:0006401	RNA catabolic process
GO:0045071	negative regulation of viral genome replication
GO:0045087	innate immune response
GO:0051607	defense response to virus
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic