InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Isg20

Summary

InnateDB Gene

IDBG-193515.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Isg20

Gene Name

interferon-stimulated protein

Synonyms

1600023I01Rik; 2010107M23Rik; 20kDa; DnaQL; HEM45

Species

Mus musculus

Ensembl Gene

ENSMUSG00000039236

Encoded Proteins

IDBP-193519

interferon-stimulated protein

IDBP-400534

interferon-stimulated protein

IDBP-400533

interferon-stimulated protein

IDBP-400532

interferon-stimulated protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 15064795

[Homo sapiens] ISG20 is an IFN-induced 3'-5' exonuclease that is strongly induced by viral double stranded RNA and is activated by RELA/NFKB1.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000172183:

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:78913424-78920362

Strand

Forward strand

Band

Transcripts

ENSMUST00000038142	ENSMUSP00000040080
ENSMUST00000121645	ENSMUSP00000112621
ENSMUST00000118867	ENSMUSP00000112480
ENSMUST00000120331	ENSMUSP00000113255
ENSMUST00000133042

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000175	3'-5'-exoribonuclease activity
GO:0003676	nucleic acid binding
GO:0004527	exonuclease activity
GO:0008310	single-stranded DNA 3'-5' exodeoxyribonuclease activity
GO:0008859	exoribonuclease II activity
GO:0030619	U1 snRNA binding
GO:0030620	U2 snRNA binding
GO:0034511	U3 snoRNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000738	DNA catabolic process, exonucleolytic
GO:0006364	rRNA processing
GO:0006401	RNA catabolic process
GO:0009615	response to virus
GO:0045071	negative regulation of viral genome replication
GO:0045087	innate immune response
GO:0051607	defense response to virus
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0015030	Cajal body
GO:0016605	PML body

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000172183

View Gene Order

ENSBTAG00000014762

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_25162

Interferon alpha/beta signaling pathway

REACT_75790

Cytokine Signaling in Immune system pathway

REACT_25229

Interferon Signaling pathway

REACT_6900

Immune System pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q9JL16

TrEMBL

UniProt Splice Variant

Entrez Gene

57444

UniGene

RefSeq

NM_001291220 XM_006541026 XM_006541027 XM_006541028 NM_001113527 NM_020583

OMIM

CCDS

CCDS71982 CCDS21376

HPRD

IMGT

MGI ID

MGI:1928895

MGI Symbol

Isg20

EMBL

AF217484 AK008139 AK008171 AK008353 BC022751

GenPept

AAF59917 AAH22751 BAB25487 BAB25509 BAB25623

RNA Seq Atlas

57444