InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc17a5

Summary

InnateDB Protein

IDBP-400577.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc17a5

Protein Name

solute carrier family 17 (anion/sugar transporter), member 5

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000113340

InnateDB Gene

IDBG-187019 (Slc17a5)

Protein Structure

UniProt Annotation

Function

Transports glucuronic acid and free sialic acid out of the lysosome after it is cleaved from sialoglycoconjugates undergoing degradation, this is required for normal CNS myelination. Mediates aspartate and glutamate membrane potential- dependent uptake into synaptic vesicles and synaptic-like microvesicles. Also functions as an electrogenic 2NO(3)(-)/H(+) cotransporter in the plasma membrane of salivary gland acinar cells, mediating the physiological nitrate efflux, 25% of the circulating nitrate ions is typically removed and secreted in saliva (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}. Lysosome membrane {ECO:0000250}; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015136	sialic acid transmembrane transporter activity
GO:0015293	symporter activity
GO:0022857	transmembrane transporter activity

Biological Process

GO:0006865	amino acid transport
GO:0015739	sialic acid transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005765	lysosomal membrane
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030054	cell junction
GO:0030672	synaptic vesicle membrane

Protein Structure and Domains

PDB ID

MGI:1924105

InterPro

IPR005828 General substrate transporter
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter

PFAM

PF00083
PF07690

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BN82

PhosphoSite