Version 5.4
Mus musculus Protein: Csf1
Summary
InnateDB Protein IDBP-400595.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Csf1
Protein Name colony stimulating factor 1 (macrophage)
Synonyms C87615; Csfm; MCSF; op;
Species Mus musculus
Ensembl Protein ENSMUSP00000112832
InnateDB Gene IDBG-185535 (Csf1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 6 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0008083 growth factor activity
Biological Process
GO:0001954 positive regulation of cell-matrix adhesion
GO:0002158 osteoclast proliferation
GO:0030278 regulation of ossification
GO:0030335 positive regulation of cell migration
GO:0040018 positive regulation of multicellular organism growth
GO:0042488 positive regulation of odontogenesis of dentin-containing tooth
GO:0045651 positive regulation of macrophage differentiation
GO:0045657 positive regulation of monocyte differentiation
GO:0045672 positive regulation of osteoclast differentiation
GO:0045860 positive regulation of protein kinase activity
GO:0046579 positive regulation of Ras protein signal transduction
GO:0048873 homeostasis of number of cells within a tissue
GO:0060444 branching involved in mammary gland duct morphogenesis
GO:0060611 mammary gland fat development
GO:0060763 mammary duct terminal end bud growth
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1339753
InterPro IPR008001 Macrophage colony stimulating factor-1
IPR009079 Four-helical cytokine-like, core
PFAM PF05337
PRINTS
PIRSF PIRSF001948
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL D3YTW1
UniProt Splice Variant
Entrez Gene 12977
UniGene Mm.795
RefSeq
MGI ID
MGI Symbol Csf1
OMIM
CCDS
HPRD
IMGT
EMBL AC140786
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca