InnateDB Protein
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IDBP-400596.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Csf1
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Protein Name
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colony stimulating factor 1 (macrophage)
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Synonyms
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C87615; Csfm; MCSF; op;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000113136
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InnateDB Gene
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IDBG-185535 (Csf1)
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Protein Structure
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Function |
Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.
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Subcellular Localization |
Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.Processed macrophage colony-stimulating factor 1: Secreted, extracellular space {ECO:0000250}.
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Disease Associations |
Note=A defect in Csf1 is the cause of osteopetrosis. Osteopetrotic mice (op/op) are severely deficient in mature macrophages and osteoclasts, display failed tooth eruption, and have a restricted capacity for bone remodeling. {ECO:0000269PubMed:2188141}.
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated |
Total |
11
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
5
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
7 [view]
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Molecular Function |
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Biological Process |
GO:0001503
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ossification
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GO:0001954
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positive regulation of cell-matrix adhesion
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GO:0002158
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osteoclast proliferation
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GO:0003006
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developmental process involved in reproduction
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GO:0006954
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inflammatory response
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GO:0010628
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positive regulation of gene expression
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GO:0010744
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positive regulation of macrophage derived foam cell differentiation
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GO:0030225
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macrophage differentiation
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GO:0030278
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regulation of ossification
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GO:0030316
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osteoclast differentiation
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GO:0030335
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positive regulation of cell migration
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GO:0032946
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positive regulation of mononuclear cell proliferation
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GO:0040018
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positive regulation of multicellular organism growth
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GO:0042476
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odontogenesis
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GO:0042488
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positive regulation of odontogenesis of dentin-containing tooth
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GO:0045087
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innate immune response
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GO:0045651
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positive regulation of macrophage differentiation
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GO:0045657
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positive regulation of monocyte differentiation
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GO:0045672
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positive regulation of osteoclast differentiation
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GO:0045860
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positive regulation of protein kinase activity
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GO:0046579
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positive regulation of Ras protein signal transduction
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GO:0048873
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homeostasis of number of cells within a tissue
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GO:0060444
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branching involved in mammary gland duct morphogenesis
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GO:0060611
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mammary gland fat development
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GO:0060763
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mammary duct terminal end bud growth
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Cellular Component |
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PDB ID |
MGI:1339753
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InterPro |
IPR008001
Macrophage colony stimulating factor-1
IPR009079
Four-helical cytokine-like, core
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PFAM |
PF05337
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PRINTS |
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PIRSF |
PIRSF001948
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P07141
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PhosphoSite |
PhosphoSite-P07141
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
12977
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UniGene |
Mm.795
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RefSeq |
NP_001107001
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MGI ID |
4ADQ
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MGI Symbol |
Csf1
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OMIM |
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CCDS |
CCDS51044
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HPRD |
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IMGT |
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EMBL |
AK138489
AK154872
AK160995
BC025593
BC066187
BC066200
BC066205
CH466607
M15692
M21149
M21952
M81316
M84361
X05010
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GenPept |
AAA03032
AAA19866
AAA37480
AAA37481
AAA37482
AAH25593
AAH66187
AAH66200
AAH66205
BAE23681
BAE32893
BAE36140
CAA28660
EDL01916
EDL01919
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