InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Btc

Summary

InnateDB Protein

IDBP-400598.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Btc

Protein Name

betacellulin, epidermal growth factor family member

Synonyms

Bcn;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000112765

InnateDB Gene

IDBG-394187 (Btc)

Protein Structure

UniProt Annotation

Function

Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. {ECO:0000269PubMed:21897861}.

Subcellular Localization

Betacellulin: Secreted, extracellular space.Probetacellulin: Cell membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Found in several mouse tissues including kidney, uterus and liver, as well as in beta tumor cell line and MCF-7 cells. It is not detected in the brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005154	epidermal growth factor receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0007173	epidermal growth factor receptor signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0035810	positive regulation of urine volume
GO:0043066	negative regulation of apoptotic process
GO:0045597	positive regulation of cell differentiation
GO:0045840	positive regulation of mitosis
GO:0048146	positive regulation of fibroblast proliferation
GO:0051781	positive regulation of cell division