Version 5.4
Mus musculus Gene: Btc
Summary
InnateDB Gene IDBG-394187.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Btc
Gene Name betacellulin, epidermal growth factor family member
Synonyms Bcn
Species Mus musculus
Ensembl Gene ENSMUSG00000082361
Encoded Proteins
IDBP-400598
betacellulin, epidermal growth factor family member
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the epidermal growth factor (EGF) family. These growth factors are ligands for the EGFR/ErbB receptor tyrosine kinases, and play roles in cell growth and differentiation. The encoded protein is synthesized as a transmembrane precursor that is proteolytically cleaved to generate a mature peptide, and plays a role in the differentiation of pancreatic beta cells. This gene may also play a protective role in acute pancreatitis, whereas increased expression of this gene may contribute to diabetic macular edema. Gene therapy using combinations of this gene and other pancreas-specific transcription factors may induce islet neogenesis and remediate hyperglycemia in type 1 diabetes. [provided by RefSeq, Apr 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:91357261-91402994
Strand Reverse strand
Band E2
Transcripts
ENSMUST00000121044 ENSMUSP00000112765
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005154 epidermal growth factor receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
Biological Process
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0008284 positive regulation of cell proliferation
GO:0035810 positive regulation of urine volume
GO:0043066 negative regulation of apoptotic process
GO:0045597 positive regulation of cell differentiation
GO:0045840 positive regulation of mitosis
GO:0048146 positive regulation of fibroblast proliferation
GO:0051781 positive regulation of cell division
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000174808
View Gene Order
ENSBTAG00000004237
Not yet available
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_198574
Nuclear signaling by ERBB4 pathway
REACT_188199
Signaling by the B Cell Receptor (BCR) pathway
REACT_188191
Signaling by ERBB2 pathway
REACT_205300
PI3K/AKT activation pathway
REACT_189085
Disease pathway
REACT_188177
Signaling by FGFR in disease pathway
REACT_188579
Signaling by ERBB4 pathway
REACT_188578
Signaling by SCF-KIT pathway
REACT_188574
SHC1 events in ERBB2 signaling pathway
REACT_226341
PIP3 activates AKT signaling pathway
REACT_230745
Immune System pathway
REACT_230639
Downstream signal transduction pathway
REACT_231729
Downstream signaling of activated FGFR pathway
REACT_196588
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_188580
SHC1 events in ERBB4 signaling pathway
REACT_203296
PI3K events in ERBB4 signaling pathway
REACT_223993
PI-3K cascade pathway
REACT_242976
Signaling by EGFR pathway
REACT_213364
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_188204
Fc epsilon receptor (FCERI) signaling pathway
REACT_226735
PI3K/AKT Signaling in Cancer pathway
REACT_248921
Signalling by NGF pathway
REACT_229531
Adaptive Immune System pathway
REACT_263353
Signaling by PDGF pathway
REACT_206286
GAB1 signalosome pathway
REACT_237883
NGF signalling via TRKA from the plasma membrane pathway
REACT_215348
PI3K events in ERBB2 signaling pathway
REACT_188257
Signal Transduction pathway
REACT_188528
GRB2 events in ERBB2 signaling pathway
REACT_242456
Signaling by FGFR pathway
REACT_188180
Signaling by EGFR in Cancer pathway
REACT_209507
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_188188
DAP12 interactions pathway
REACT_188185
DAP12 signaling pathway
KEGG
mmu04012
ErbB signaling pathway pathway
INOH
INOH website
GPCR signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_75829
PIP3 activates AKT signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_12464
PI3K/AKT activation pathway
REACT_12578
GAB1 signalosome pathway
REACT_9417
Signaling by EGFR pathway
REACT_116005
SHC1 events in ERBB4 signaling pathway
REACT_116022
Nuclear signaling by ERBB4 pathway
REACT_115961
PI3K events in ERBB4 signaling pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_116008
PI3K events in ERBB2 signaling pathway
REACT_115854
GRB2 events in ERBB2 signaling pathway
REACT_115993
SHC1 events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_21270
PI-3K cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_147727
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_163769
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_6802
Innate Immune System pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_111102
Signal Transduction pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_147723
PI3K/AKT Signaling in Cancer pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_116125
Disease pathway
KEGG
hsa04012
ErbB signaling pathway pathway
INOH
INOH website
GPCR signaling pathway
PID NCI
erbb4_pathway
ErbB4 signaling events
erbb_network_pathway
ErbB receptor signaling network
Cross-References
SwissProt Q05928
TrEMBL Q3TP84 Q543J8
UniProt Splice Variant
Entrez Gene 12223
UniGene Mm.2024
RefSeq NM_007568
OMIM
CCDS CCDS19422
HPRD
IMGT
MGI ID MGI:99439
MGI Symbol Btc
EMBL AF368017 AF368018 AF368019 AF368020 AF368021 AK050206 AK076272 AK164633 BC119152 BC119154 CH466617 L08394
GenPept AAA40511 AAI19153 AAI19155 AAM21214 BAC34122 BAC36281 BAE37853 EDL05292
RNA Seq Atlas 12223

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca