InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ick

Summary

InnateDB Protein

IDBP-400602.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ick

Protein Name

intestinal cell kinase

Synonyms

2210420N10Rik; AI848300; Mrk;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000112961

InnateDB Gene

IDBG-186294 (Ick)

Protein Structure

UniProt Annotation

Function

May play a role in cardiac development. {ECO:0000250UniProtKB:Q62726}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in colon and lung, lower levels present in heart, esophagus, stomach, small intestine and ovary. Localizes to the crypt region of large and small intestine. {ECO:0000269PubMed:10699974}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004693	cyclin-dependent protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007049	cell cycle
GO:0007165	signal transduction
GO:0007275	multicellular organismal development
GO:0035556	intracellular signal transduction

Cellular Component

GO:0005829	cytosol
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

MGI:1934157

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt