Version 5.4
Mus musculus Gene: Ick
Summary
InnateDB Gene IDBG-186294.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ick
Gene Name intestinal cell kinase
Synonyms 2210420N10Rik; AI848300; Mrk
Species Mus musculus
Ensembl Gene ENSMUSG00000009828
Encoded Proteins
IDBP-186296
intestinal cell kinase
IDBP-186298
intestinal cell kinase
IDBP-400602
intestinal cell kinase
IDBP-400599
intestinal cell kinase
IDBP-538423
intestinal cell kinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112144:
Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. The protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. Alternative splicing has been observed at this locus and two variants, encoding the same isoform, have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:78109192-78172107
Strand Forward strand
Band E1
Transcripts
ENSMUST00000009972 ENSMUSP00000009972
ENSMUST00000044551 ENSMUSP00000048234
ENSMUST00000118869 ENSMUSP00000112961
ENSMUST00000117330 ENSMUSP00000113655
ENSMUST00000125615 ENSMUSP00000115522
ENSMUST00000149821
ENSMUST00000142776
ENSMUST00000142402
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0007049 cell cycle
GO:0007165 signal transduction
GO:0007275 multicellular organismal development
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005829 cytosol
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000112144
View Gene Order
ENSBTAG00000015590
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.288719 Mm.400866 Mm.414452 Mm.483232
RefSeq NM_001163780 NM_019987 XM_006511304 XM_006511305
OMIM
CCDS CCDS40697
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca