InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rlim

Summary

InnateDB Protein

IDBP-400621.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rlim

Protein Name

ring finger protein, LIM domain interacting

Synonyms

AL022832; AW743871; Ha1r; Rlim1; Rnf12;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000112820

InnateDB Gene

IDBG-165932 (Rlim)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase that acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex- related dosage differences of X-encoded genes in somatic cells of female placental mammals. {ECO:0000269PubMed:10431247, ECO:0000269PubMed:11882901, ECO:0000269PubMed:19945382, ECO:0000269PubMed:22596162}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:19945382}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0016567	protein ubiquitination
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0060816	random inactivation of X chromosome