InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sirt6

Summary

InnateDB Protein

IDBP-400652.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sirt6

Protein Name

sirtuin 6 (silent mating type information regulation 2, homolog) 6 (S. cerevisiae)

Synonyms

2810449N18Rik; AI043036; Sir2l6;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000113953

InnateDB Gene

IDBG-179184 (Sirt6)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	2 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0046969	NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0070403	NAD+ binding

Biological Process

GO:0010569	regulation of double-strand break repair via homologous recombination
GO:0070932	histone H3 deacetylation

Cellular Component

GO:0005654	nucleoplasm
GO:0005724	nuclear telomeric heterochromatin

Protein Structure and Domains

PDB ID

MGI:1354161

InterPro

IPR003000 Sirtuin family
IPR026590 Sirtuin family, catalytic core domain
IPR029035 DHS-like NAD/FAD-binding domain

PFAM

PF02146

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

Q3UKP1

UniProt Splice Variant

Entrez Gene

50721

UniGene

Mm.25643

RefSeq

NP_001156902

MGI ID

MGI Symbol

Sirt6

OMIM

CCDS

CCDS48645

HPRD

IMGT

EMBL

AC153919 AK145929

GenPept

BAE26760