InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hipk1

Summary

InnateDB Protein

IDBP-400678.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hipk1

Protein Name

homeodomain interacting protein kinase 1

Synonyms

1110062K04Rik; Myak;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000114065

InnateDB Gene

IDBG-181648 (Hipk1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007224	smoothened signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0009952	anterior/posterior pattern specification
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

Cellular Component

GO:0005737	cytoplasm
GO:0016605	PML body
GO:0016607	nuclear speck

Protein Structure and Domains

PDB ID

MGI:1314873

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt