InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nfic

Summary

InnateDB Protein

IDBP-400682.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nfic

Protein Name

nuclear factor I/C

Synonyms

1110019L22Rik; 1500041O16Rik; AA589446; AI746521; NF1-C;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000113046

InnateDB Gene

IDBG-178485 (Nfic)

Protein Structure

UniProt Annotation

Function

Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Highest levels in skeletal muscle. Lower levels in heart, liver, kidney, lung and brain. Very low levels in testis and spleen.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001159	core promoter proximal region DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006260	DNA replication
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0042475	odontogenesis of dentin-containing tooth
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005667	transcription factor complex

Protein Structure and Domains

PDB ID

MGI:109591

InterPro

IPR000647 CTF transcription factor/nuclear factor 1
IPR003619 MAD homology 1, Dwarfin-type
IPR013019 MAD homology, MH1
IPR019548 CTF transcription factor/nuclear factor 1, N-terminal
IPR020604 CTF transcription factor/nuclear factor 1, DNA-binding domain

PFAM

PF00859
PF03165
PF10524

PRINTS

PIRSF

SMART

SM00523

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P70255