InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Nfic

Summary

InnateDB Gene

IDBG-178485.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nfic

Gene Name

nuclear factor I/C

Synonyms

1110019L22Rik; 1500041O16Rik; AA589446; AI746521; NF1-C

Species

Mus musculus

Ensembl Gene

ENSMUSG00000055053

Encoded Proteins

IDBP-178487

nuclear factor I/C

IDBP-178489

nuclear factor I/C

IDBP-271124

nuclear factor I/C

IDBP-400682

nuclear factor I/C

IDBP-536897

nuclear factor I/C

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000141905:
The protein encoded by this gene belongs to the CTF/NF-I family. These are dimeric DNA-binding proteins, and function as cellular transcription factors and as replication factors for adenovirus DNA replication. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:81396186-81431005

Strand

Reverse strand

Band

Transcripts

ENSMUST00000020461	ENSMUSP00000020461
ENSMUST00000078185	ENSMUSP00000077317
ENSMUST00000105321	ENSMUSP00000100958
ENSMUST00000117966	ENSMUSP00000113046
ENSMUST00000152670
ENSMUST00000140916	ENSMUSP00000114469

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001159	core promoter proximal region DNA binding
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006260	DNA replication
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0042475	odontogenesis of dentin-containing tooth
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter