InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CTSG

Summary

InnateDB Protein

IDBP-4007.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CTSG

Protein Name

cathepsin G

Synonyms

CATG; CG;

Species

Homo sapiens

Ensembl Protein

ENSP00000216336

InnateDB Gene

IDBG-4005 (CTSG)

Protein Structure

UniProt Annotation

Function

Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe- CH2Cl and phenylmethylsulfonyl fluoride. {ECO:0000269PubMed:1861080, ECO:0000269PubMed:1937776, ECO:0000269PubMed:8194606}.

Subcellular Localization

Cell surface {ECO:0000269PubMed:8194606}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0008201	heparin binding
GO:0008233	peptidase activity

Biological Process

GO:0002003	angiotensin maturation
GO:0006508	proteolysis
GO:0006955	immune response
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0032496	response to lipopolysaccharide
GO:0044130	negative regulation of growth of symbiont in host
GO:0044267	cellular protein metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0050778	positive regulation of immune response
GO:0050830	defense response to Gram-positive bacterium
GO:0050832	defense response to fungus
GO:0070946	neutrophil mediated killing of gram-positive bacterium

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0030141	secretory granule
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome