Version 5.4
Homo sapiens Gene: CTSG
Summary
InnateDB Gene IDBG-4005.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CTSG
Gene Name cathepsin G
Synonyms CATG; CG
Species Homo sapiens
Ensembl Gene ENSG00000100448
Encoded Proteins
IDBP-4007
cathepsin G
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 18762176
CTSG, a cathepsin, is a key modulator of cell death and inflammatory responses.
PMID 20676107
ELANE and CTSG, together with externalized nucleosomes, promote coagulation and intravascular thrombus growth in vivo. During systemic infection, activation of coagulation fosters compartmentalization of bacteria in liver microvessels and reduces bacterial invasion into tissue.
Entrez Gene
Summary The protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes. The encoded protease has a specificity similar to that of chymotrypsin C, and may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes. The encoded protease has a specificity similar to that of chymotrypsin C, and may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. In addition, the encoded protein is antimicrobial, with bacteriocidal activity against S. aureus and N. gonorrhoeae. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq, Sep 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:24573522-24576260
Strand Reverse strand
Band q12
Transcripts
ENST00000216336 ENSP00000216336
ENST00000552252
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0008201 heparin binding
GO:0008233 peptidase activity
Biological Process
GO:0002003 angiotensin maturation
GO:0006508 proteolysis
GO:0006955 immune response
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
GO:0032496 response to lipopolysaccharide
GO:0044130 negative regulation of growth of symbiont in host
GO:0044267 cellular protein metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0050778 positive regulation of immune response
GO:0050830 defense response to Gram-positive bacterium
GO:0050832 defense response to fungus
GO:0070946 neutrophil mediated killing of gram-positive bacterium
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0030141 secretory granule
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000040314
View Gene Order
Pathways
NETPATH
REACTOME
REACT_147707
Metabolism of Angiotensinogen to Angiotensins pathway
REACT_15428
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) pathway
REACT_118682
Activation of Matrix Metalloproteinases pathway
REACT_118779
Extracellular matrix organization pathway
REACT_118572
Degradation of the extracellular matrix pathway
REACT_17015
Metabolism of proteins pathway
REACT_160078
Peptide hormone metabolism pathway
KEGG
hsa04614
Renin-angiotensin system pathway
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa05322
Systemic lupus erythematosus pathway
hsa04142
Lysosome pathway
hsa05146
Amoebiasis pathway
INOH
PID NCI
upa_upar_pathway
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Cross-References
SwissProt P08311
TrEMBL
UniProt Splice Variant
Entrez Gene 1511
UniGene Hs.421724
RefSeq NM_001911
HUGO HGNC:2532
OMIM 116830
CCDS CCDS9631
HPRD
IMGT
EMBL BC014460 CH471078 CR456807 CR541704 J04990 M16117
GenPept AAA51919 AAA52126 AAH14460 CAG33088 CAG46505 EAW66006
RNA Seq Atlas 1511

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca