InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Med12

Summary

InnateDB Protein

IDBP-400707.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Med12

Protein Name

mediator of RNA polymerase II transcription, subunit 12 homolog (yeast)

Synonyms

230kDa; Mopa; OPA-1; Tnrc11; Trap230;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000112729

InnateDB Gene

IDBG-253359 (Med12)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 68 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	68 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001104	RNA polymerase II transcription cofactor activity
GO:0001190	RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0003682	chromatin binding
GO:0008013	beta-catenin binding
GO:0008134	transcription factor binding

Biological Process

GO:0001843	neural tube closure
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007507	heart development
GO:0014003	oligodendrocyte development
GO:0014044	Schwann cell development
GO:0019827	stem cell maintenance
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060070	canonical Wnt signaling pathway
GO:0060071	Wnt signaling pathway, planar cell polarity pathway
GO:0090245	axis elongation involved in somitogenesis

Cellular Component

GO:0016592

mediator complex

Protein Structure and Domains

PDB ID

MGI:1926212

InterPro

IPR019035 Mediator complex, subunit Med12
IPR021989 Mediator complex, subunit Med12, catenin-binding
IPR021990 Mediator complex, subunit Med12, LCEWAV-domain

PFAM

PF09497
PF12144
PF12145

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-