Version 5.4
Mus musculus Protein: Gtf2a2
Summary
InnateDB Protein IDBP-400738.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gtf2a2
Protein Name general transcription factor II A, 2
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000113697
InnateDB Gene IDBG-181923 (Gtf2a2)
Protein Structure
UniProt Annotation
Function TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001103 RNA polymerase II repressing transcription factor binding
GO:0003713 transcription coactivator activity
GO:0017025 TBP-class protein binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly
Cellular Component
GO:0005672 transcription factor TFIIA complex
Protein Structure and Domains
PDB ID MGI:1933289
InterPro IPR003194 Transcription initiation factor IIA, gamma subunit
IPR009083 Transcription factor IIA, helical
IPR009088 Transcription factor IIA, beta-barrel
IPR015871 Transcription initiation factor IIA, gamma subunit, C-terminal
IPR015872 Transcription initiation factor IIA, gamma subunit, N-terminal
PFAM PF02751
PF02268
PRINTS
PIRSF PIRSF009415
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q80ZM7
PhosphoSite PhosphoSite-Q80ZM7
TrEMBL Q3TE88
UniProt Splice Variant
Entrez Gene 235459
UniGene Mm.472948
RefSeq NP_001269012
MGI ID
MGI Symbol Gtf2a2
OMIM
CCDS CCDS52851
HPRD
IMGT
EMBL AC137108 AK050621 AK169778 BC048705 CH466522
GenPept AAH48705 BAE20680 BAE41360 EDL26180 EDL26183 EDL26187

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca