InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Farp2

Summary

InnateDB Protein

IDBP-400748.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Farp2

Protein Name

FERM, RhoGEF and pleckstrin domain protein 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000112725

InnateDB Gene

IDBG-183444 (Farp2)

Protein Structure

UniProt Annotation

Function

Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity (PubMed:23375260 and PubMed:20702777). Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion. {ECO:0000269PubMed:12351724, ECO:0000269PubMed:16286926, ECO:0000269PubMed:20702777, ECO:0000269PubMed:23375260}.

Subcellular Localization

Disease Associations

Tissue Specificity

Detected in adult brain, lung and testis. Detected in embryonic hippocampus and brain cortex. {ECO:0000269PubMed:12351724}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0008092	cytoskeletal protein binding
GO:0030676	Rac guanyl-nucleotide exchange factor activity

Biological Process

GO:0007155	cell adhesion
GO:0016322	neuron remodeling
GO:0016601	Rac protein signal transduction
GO:0030316	osteoclast differentiation
GO:0031532	actin cytoskeleton reorganization
GO:0032314	regulation of Rac GTPase activity
GO:0032319	regulation of Rho GTPase activity
GO:0032321	positive regulation of Rho GTPase activity
GO:0033623	regulation of integrin activation
GO:0035023	regulation of Rho protein signal transduction
GO:0071526	semaphorin-plexin signaling pathway
GO:0071800	podosome assembly

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0019898	extrinsic component of membrane

Protein Structure and Domains

PDB ID

MGI:2385126

InterPro

IPR000219 Dbl homology (DH) domain
IPR000299 FERM domain
IPR000798 Ezrin/radixin/moesin like
IPR001849 Pleckstrin homology domain
IPR014847 FERM adjacent (FA)
IPR018979 FERM, N-terminal
IPR018980 FERM, C-terminal PH-like domain
IPR019748 FERM central domain
IPR019749 Band 4.1 domain
IPR019750 Band 4.1 family
IPR029071 Ubiquitin-related domain

PFAM

PF00621
PF00169
PF08736
PF09379
PF09380
PF00373

PRINTS

PR00661
PR00935

PIRSF

SMART

SM00325
SM00233
SM00295

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt