InnateDB Protein
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IDBP-400791.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Aktip
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Protein Name
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thymoma viral proto-oncogene 1 interacting protein
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Synonyms
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AL023020; Fif; Ft; Ft1; Fts;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000112375
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InnateDB Gene
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IDBG-179747 (Aktip)
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Protein Structure
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Function |
Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
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Disease Associations |
Note=Defects in Aktip are a cause of embryonic death in homozygous animals. Death occurs at about 10 days of development. Symptoms include loss of left-right asymmetry, malformation of the developing brain and of the spinal cord, syndactyly and polydactyly. Heterozygous animals are characterized by polydactyly and thymic hyperplasia. {ECO:0000269PubMed:7956835}.
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Tissue Specificity |
Ubiquitous. Highest expression in kidney, testis and brain and lowest in spleen and liver. {ECO:0000269PubMed:9383278}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
0
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
38 [view]
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Molecular Function |
Accession |
GO Term |
GO:0016881
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acid-amino acid ligase activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:3693832
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InterPro |
IPR000608
Ubiquitin-conjugating enzyme, E2
IPR016135
Ubiquitin-conjugating enzyme/RWD-like
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PFAM |
PF00179
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q64362
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PhosphoSite |
PhosphoSite-Q64362
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TrEMBL |
D3Z2J4
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UniProt Splice Variant |
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Entrez Gene |
14339
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UniGene |
Mm.487451
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RefSeq |
XP_006530732
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MGI ID |
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MGI Symbol |
Aktip
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OMIM |
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CCDS |
CCDS22519
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HPRD |
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IMGT |
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EMBL |
AC122441
AK146459
AK158704
BC008130
CH466525
X71978
Z67963
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GenPept |
AAH08130
BAE27187
BAE34620
CAA50800
CAA91902
EDL11072
EDL11073
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