InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Msn

Summary

InnateDB Protein

IDBP-400806.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Msn

Protein Name

moesin

Synonyms

C78546;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000113071

InnateDB Gene

IDBG-160809 (Msn)

Protein Structure

UniProt Annotation

Function

Probably involved in connections of major cytoskeletal structures to the plasma membrane.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:9856983}; Peripheral membrane protein {ECO:0000269PubMed:9856983}; Cytoplasmic side {ECO:0000269PubMed:9856983}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:9856983}. Apical cell membrane {ECO:0000269PubMed:9856983}; Peripheral membrane protein {ECO:0000269PubMed:9856983}; Cytoplasmic side {ECO:0000269PubMed:9856983}. Cell projection, microvillus membrane {ECO:0000269PubMed:9856983}; Peripheral membrane protein {ECO:0000269PubMed:9856983}; Cytoplasmic side {ECO:0000269PubMed:9856983}. Note=Phosphorylated form is enriched in microvilli-like structures at apical membrane. Increased cell membrane localization of both phosphorylated and non- phosphorylated forms seen after thrombin treatment (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 52 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	52 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003725	double-stranded RNA binding
GO:0003779	actin binding
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding
GO:0019901	protein kinase binding
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0007159	leukocyte cell-cell adhesion
GO:0010628	positive regulation of gene expression
GO:0022614	membrane to membrane docking
GO:0050900	leukocyte migration
GO:0061028	establishment of endothelial barrier
GO:2000401	regulation of lymphocyte migration

Cellular Component

GO:0001931	uropod
GO:0005615	extracellular space
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005902	microvillus
GO:0005925	focal adhesion
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0019898	extrinsic component of membrane
GO:0030175	filopodium
GO:0031528	microvillus membrane
GO:0045177	apical part of cell
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle

Protein Structure and Domains

PDB ID

MGI:97167

InterPro

IPR000299 FERM domain
IPR000798 Ezrin/radixin/moesin like
IPR008954 Moesin tail domain
IPR011174 Ezrin/radixin/moesin
IPR011259 Ezrin/radixin/moesin, C-terminal
IPR018979 FERM, N-terminal
IPR018980 FERM, C-terminal PH-like domain
IPR019748 FERM central domain
IPR019749 Band 4.1 domain
IPR019750 Band 4.1 family
IPR029071 Ubiquitin-related domain

PFAM

PF00769
PF09379
PF09380
PF00373

PRINTS

PR00661
PR00935

PIRSF

PIRSF002305

SMART

SM00295

TIGRFAMs

Post-translational Modifications

Modification

Cross-References