InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Msn

Summary

InnateDB Gene

IDBG-160809.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Msn

Gene Name

moesin

Synonyms

C78546

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031207

Encoded Proteins

IDBP-400806

moesin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000147065:
Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:96096042-96168552

Strand

Forward strand

Band

Transcripts

ENSMUST00000117399	ENSMUSP00000113071
ENSMUST00000149985
ENSMUST00000135027

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 52 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	52 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003725	double-stranded RNA binding
GO:0003779	actin binding
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding
GO:0019901	protein kinase binding
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0007159	leukocyte cell-cell adhesion
GO:0010628	positive regulation of gene expression
GO:0022614	membrane to membrane docking
GO:0050900	leukocyte migration
GO:0061028	establishment of endothelial barrier
GO:2000401	regulation of lymphocyte migration

Cellular Component

GO:0001931	uropod
GO:0005615	extracellular space
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005902	microvillus
GO:0005925	focal adhesion
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0019898	extrinsic component of membrane
GO:0030175	filopodium
GO:0031528	microvillus membrane
GO:0045177	apical part of cell
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000147065

View Gene Order

ENSBTAG00000003418

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04810

Regulation of actin cytoskeleton pathway

mmu04670

Leukocyte transendothelial migration pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_6

KitReceptor pathway

REACTOME

REACT_22365

Recycling pathway of L1 pathway

REACT_22205

L1CAM interactions pathway

REACT_111045

Developmental Biology pathway

REACT_18266

Axon guidance pathway

KEGG

hsa04810

Regulation of actin cytoskeleton pathway

hsa04670

Leukocyte transendothelial migration pathway

INOH

PID NCI

er_nongenomic_pathway

Plasma membrane estrogen receptor signaling

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.138876 Mm.402264 Mm.474813

RefSeq

NM_010833

OMIM

CCDS

CCDS53139

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas