InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Afap1l2

Summary

InnateDB Protein

IDBP-400808.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Afap1l2

Protein Name

actin filament associated protein 1-like 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000113745

InnateDB Gene

IDBG-179434 (Afap1l2)

Protein Structure

UniProt Annotation

Function

May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0017124	SH3 domain binding
GO:0030296	protein tyrosine kinase activator activity
GO:0042169	SH2 domain binding

Biological Process

GO:0006954	inflammatory response
GO:0007346	regulation of mitotic cell cycle
GO:0032675	regulation of interleukin-6 production
GO:0032757	positive regulation of interleukin-8 production
GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway
GO:0045893	positive regulation of transcription, DNA-templated
GO:0061098	positive regulation of protein tyrosine kinase activity