InnateDB Protein
|
IDBP-400822.4
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Lnx1
|
Protein Name
|
ligand of numb-protein X 1
|
Synonyms
|
Lnx;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000113837
|
InnateDB Gene
|
IDBG-171744 (Lnx1)
|
Protein Structure
|
|
Function |
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65.Isoform 2 provides an endocytic scaffold for IGSF5/JAM4.
|
Subcellular Localization |
Cytoplasm.
|
Disease Associations |
|
Tissue Specificity |
Isoform 1 and isoform 2 are expressed in the heart. Isoform 1 is also expressed in kidney, lung and skeletal muscle while isoform 2 is also expressed in brain. {ECO:0000269PubMed:9535908}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 136 interaction(s) predicted by orthology.
Experimentally validated |
Total |
17
[view]
|
Protein-Protein |
17
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
136 [view]
|
|
|
Molecular Function |
|
Biological Process |
GO:0006511
|
ubiquitin-dependent protein catabolic process
|
GO:0042787
|
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
|
GO:0051260
|
protein homooligomerization
|
|
Cellular Component |
|
PDB ID |
MGI:1278335
|
InterPro |
IPR001478
PDZ domain
IPR029017
Enolase N-terminal domain-like
|
PFAM |
PF00595
PF13180
|
PRINTS |
|
PIRSF |
|
SMART |
SM00228
|
TIGRFAMs |
|
Modification |
|
SwissProt |
O70263
|
PhosphoSite |
PhosphoSite-
|
TrEMBL |
E9Q4N3
|
UniProt Splice Variant |
|
Entrez Gene |
16924
|
UniGene |
|
RefSeq |
NP_001153051
|
MGI ID |
3VQG
|
MGI Symbol |
Lnx1
|
OMIM |
|
CCDS |
CCDS19347
|
HPRD |
|
IMGT |
|
EMBL |
AC120865
AC164523
AF034745
AF034746
AK044127
BC040367
BC139771
CH466524
|
GenPept |
AAC40075
AAC40076
AAH40367
AAI39772
BAC31789
EDL37875
|
|
|