InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pttg1

Summary

InnateDB Protein

IDBP-400834.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pttg1

Protein Name

pituitary tumor-transforming gene 1

Synonyms

AW555095; C87862; Pttg; Pttg3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000112841

InnateDB Gene

IDBG-163985 (Pttg1)

Protein Structure

UniProt Annotation

Function

Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of p53/TP53. The negative regulation of p53/TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Note=Has strong transforming capabilities on a variety of cell lines including NIH 3T3 fibroblasts and on athymic nude mice. The transforming capability may be due to its interaction and regulation of p53/TP53 pathway.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004869	cysteine-type endopeptidase inhibitor activity
GO:0017124	SH3 domain binding
GO:0031072	heat shock protein binding
GO:0043022	ribosome binding

Biological Process

GO:0001558	regulation of cell growth
GO:0006281	DNA repair
GO:0007059	chromosome segregation
GO:0007067	mitotic nuclear division
GO:0008285	negative regulation of cell proliferation
GO:0009987	cellular process
GO:0010951	negative regulation of endopeptidase activity
GO:0045143	homologous chromosome segregation
GO:0051276	chromosome organization