Version 5.4
Mus musculus Protein: Mylk3
Summary
InnateDB Protein IDBP-400868.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mylk3
Protein Name myosin light chain kinase 3
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000113960
InnateDB Gene IDBG-177153 (Mylk3)
Protein Structure
UniProt Annotation
Function Kinase that phosphorylates MYL2 in vitro. Has been proposed to be calmodulin-dependent (PubMed:17885681), although MYL2 phosphorylation has also been observed in the presence or absence of calmodulin (PubMed:18202317). Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility. {ECO:0000269PubMed:17885681, ECO:0000269PubMed:18202317}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:18202317}.
Disease Associations
Tissue Specificity Restricted to cardiomyocytes (at protein level). Down-regulated in heart after experimental myocardial infarction at the protein level; no significant changes at the mRNA level. {ECO:0000269PubMed:18202317}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004683 calmodulin-dependent protein kinase activity
GO:0004687 myosin light chain kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0002528 regulation of vascular permeability involved in acute inflammatory response
GO:0006468 protein phosphorylation
GO:0045214 sarcomere organization
GO:0048769 sarcomerogenesis
GO:0055003 cardiac myofibril assembly
GO:0060298 positive regulation of sarcomere organization
GO:0071347 cellular response to interleukin-1
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0015629 actin cytoskeleton
Protein Structure and Domains
PDB ID MGI:2443063
InterPro IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF00069
PF07714
PRINTS PR00109
PIRSF
SMART SM00220
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3UIZ8
PhosphoSite PhosphoSite-Q3UIZ8
TrEMBL
UniProt Splice Variant
Entrez Gene 213435
UniGene Mm.32804
RefSeq
MGI ID
MGI Symbol Mylk3
OMIM
CCDS
HPRD
IMGT
EMBL AK031546 AK052858 AK146683 EU403565
GenPept ABY89726 BAC35177 BAE27357 BAE43277

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca