Version 5.4
Mus musculus Gene: Mylk3
Summary
InnateDB Gene IDBG-177153.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mylk3
Gene Name myosin light chain kinase 3
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000031698
Encoded Proteins
IDBP-177155
myosin light chain kinase 3
IDBP-400872
myosin light chain kinase 3
IDBP-400868
myosin light chain kinase 3
IDBP-535815
myosin light chain kinase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140795:
Phosphorylation of cardiac myosin heavy chains (see MYH7B, MIM 609928) and light chains (see MYL2, MIM 160781) by a kinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiac myocytes (Chan et al., 2008 [PubMed 18202317]).[supplied by OMIM, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:85324303-85386345
Strand Reverse strand
Band C3
Transcripts
ENSMUST00000034133 ENSMUSP00000034133
ENSMUST00000122452 ENSMUSP00000113389
ENSMUST00000121972 ENSMUSP00000113960
ENSMUST00000137290 ENSMUSP00000123372
ENSMUST00000138825
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004683 calmodulin-dependent protein kinase activity
GO:0004687 myosin light chain kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0002528 regulation of vascular permeability involved in acute inflammatory response
GO:0006468 protein phosphorylation
GO:0045214 sarcomere organization
GO:0048769 sarcomerogenesis
GO:0055003 cardiac myofibril assembly
GO:0060298 positive regulation of sarcomere organization
GO:0071347 cellular response to interleukin-1
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0015629 actin cytoskeleton
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000140795
View Gene Order
ENSBTAG00000014818
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04020
Calcium signaling pathway pathway
mmu04810
Regulation of actin cytoskeleton pathway
mmu04510
Focal adhesion pathway
mmu04270
Vascular smooth muscle contraction pathway
mmu04971
Gastric acid secretion pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
REACTOME
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04510
Focal adhesion pathway
hsa04020
Calcium signaling pathway pathway
hsa04270
Vascular smooth muscle contraction pathway
hsa04971
Gastric acid secretion pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.32804
RefSeq NM_175441 XM_006530824 XM_006530825
OMIM
CCDS CCDS40422
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca