InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ecm1

Summary

InnateDB Protein

IDBP-400911.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ecm1

Protein Name

extracellular matrix protein 1

Synonyms

AI663821; p85;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000112665

InnateDB Gene

IDBG-173351 (Ecm1)

Protein Structure

UniProt Annotation

Function

Involved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix.

Disease Associations

Tissue Specificity

Expressed in the connective tissues surronding developing long bones, but not in the cartilage. The long isoform is expressed in a number of tissues including liver, heart and lungs. The short isoform is expressed in skin and cartilage- containing tissues such as tail and front paw. No expression is found in brain. {ECO:0000269PubMed:11165938}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0004871	signal transducer activity
GO:0005134	interleukin-2 receptor binding
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0019899	enzyme binding
GO:0043236	laminin binding

Biological Process

GO:0001503	ossification
GO:0001525	angiogenesis
GO:0001938	positive regulation of endothelial cell proliferation
GO:0001960	negative regulation of cytokine-mediated signaling pathway
GO:0002828	regulation of type 2 immune response
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006954	inflammatory response
GO:0007165	signal transduction
GO:0010466	negative regulation of peptidase activity
GO:0030502	negative regulation of bone mineralization
GO:0031214	biomineral tissue development
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045766	positive regulation of angiogenesis
GO:2000404	regulation of T cell migration

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome