InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ecm1

Summary

InnateDB Gene

IDBG-173351.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ecm1

Gene Name

extracellular matrix protein 1

Synonyms

AI663821; p85

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028108

Encoded Proteins

IDBP-173353

extracellular matrix protein 1

IDBP-400911

extracellular matrix protein 1

IDBP-541198

extracellular matrix protein 1

IDBP-536416

extracellular matrix protein 1

IDBP-541454

extracellular matrix protein 1

IDBP-538894

extracellular matrix protein 1

IDBP-535118

extracellular matrix protein 1

IDBP-537406

extracellular matrix protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143369:
This gene encodes a soluble protein that is involved in endochondral bone formation, angiogenesis, and tumor biology. It also interacts with a variety of extracellular and structural proteins, contributing to the maintenance of skin integrity and homeostasis. Mutations in this gene are associated with lipoid proteinosis disorder (also known as hyalinosis cutis et mucosae or Urbach-Wiethe disease) that is characterized by generalized thickening of skin, mucosae and certain viscera. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:95734147-95739569

Strand

Reverse strand

Band

F2.1

Transcripts

ENSMUST00000029753	ENSMUSP00000029753
ENSMUST00000117507	ENSMUSP00000112665
ENSMUST00000144958
ENSMUST00000123143	ENSMUSP00000120300
ENSMUST00000131376	ENSMUSP00000114659
ENSMUST00000128885	ENSMUSP00000120820
ENSMUST00000153026	ENSMUSP00000114747
ENSMUST00000137912	ENSMUSP00000122243
ENSMUST00000155815
ENSMUST00000147217	ENSMUSP00000115524

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0004871	signal transducer activity
GO:0005134	interleukin-2 receptor binding
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0019899	enzyme binding
GO:0043236	laminin binding

Biological Process

GO:0001503	ossification
GO:0001525	angiogenesis
GO:0001938	positive regulation of endothelial cell proliferation
GO:0001960	negative regulation of cytokine-mediated signaling pathway
GO:0002828	regulation of type 2 immune response
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006954	inflammatory response
GO:0007165	signal transduction
GO:0010466	negative regulation of peptidase activity
GO:0030502	negative regulation of bone mineralization
GO:0031214	biomineral tissue development
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045766	positive regulation of angiogenesis
GO:2000404	regulation of T cell migration

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000143369

View Gene Order

ENSBTAG00000003806

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.3433 Mm.467416

RefSeq

NM_001252653 NM_007899 XM_006500985 XM_006500987

OMIM

CCDS

CCDS17619 CCDS57237

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas