Version 5.4
Mus musculus Protein: Arl6
Summary
InnateDB Protein IDBP-400980.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arl6
Protein Name ADP-ribosylation factor-like 6
Synonyms 1110018H24Rik; 2210411E14Rik; BBS3;
Species Mus musculus
Ensembl Protein ENSMUSP00000113127
InnateDB Gene IDBG-170048 (Arl6)
Protein Structure
UniProt Annotation
Function Involved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia. Together with the BBSome complex and LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May regulate cilia assembly and disassembly and subsequent ciliary signaling events such as the Wnt signaling cascade. Isoform 2 may be required for proper retinal function and organization. {ECO:0000269PubMed:20333246}.
Subcellular Localization Cell projection, cilium membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250}. Note=Appears in a pattern of punctae flanking the microtubule axoneme that likely correspond to small membrane- associated patches. Localizes to the so-called ciliary gate where vesicles carrying ciliary cargo fuse with the membrane (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Most abundant in brain and kidney. Expressed in heart and eye. Isoform 2 is expressed only in the retina. {ECO:0000269PubMed:20333246}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0005543 phospholipid binding
GO:0019001 guanyl nucleotide binding
GO:0031683 G-protein beta/gamma-subunit complex binding
GO:0046872 metal ion binding
Biological Process
GO:0006471 protein ADP-ribosylation
GO:0006612 protein targeting to membrane
GO:0006886 intracellular protein transport
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0007265 Ras protein signal transduction
GO:0016055 Wnt signaling pathway
GO:0042384 cilium assembly
GO:0045444 fat cell differentiation
GO:0051258 protein polymerization
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005879 axonemal microtubule
GO:0005930 axoneme
GO:0016020 membrane
GO:0030117 membrane coat
GO:0034464 BBSome
GO:0060170 ciliary membrane
Protein Structure and Domains
PDB ID MGI:1927136
InterPro IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
IPR001806 Small GTPase superfamily
IPR005225 Small GTP-binding protein domain
IPR006687 Small GTPase superfamily, SAR1-type
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR006762 Gtr1/RagA G protein
IPR013684 Mitochondrial Rho-like
IPR019009 Signal recognition particle receptor, beta subunit
IPR024156 Small GTPase superfamily, ARF type
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00503
PF00071
PF00025
PF04670
PF08477
PF09439
PRINTS PR00318
PR00449
PR00328
PIRSF
SMART SM00275
SM00178
SM00177
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O88848
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 56297
UniGene Mm.392505
RefSeq
MGI ID
MGI Symbol Arl6
OMIM
CCDS
HPRD
IMGT
EMBL AF031903 AK003778 AK158832
GenPept AAC62194 BAB22990 BAE34686

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca