InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Arl6

Summary

InnateDB Gene

IDBG-170048.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Arl6

Gene Name

ADP-ribosylation factor-like 6

Synonyms

1110018H24Rik; 2210411E14Rik; BBS3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022722

Encoded Proteins

IDBP-170050

ADP-ribosylation factor-like 6

IDBP-170052

ADP-ribosylation factor-like 6

IDBP-400980

ADP-ribosylation factor-like 6

IDBP-542827

ADP-ribosylation factor-like 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113966:
The protein encoded by this gene belongs to the ARF family of GTP-binding proteins. ARF proteins are important regulators of cellular traffic and are the founding members of an expanding family of homologous proteins and genomic sequences. They depart from other small GTP-binding proteins by a unique structural device that implements front-back communication from the N-terminus to the nucleotide-binding site. Studies of the mouse ortholog of this protein suggest an involvement in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:59612949-59639391

Strand

Reverse strand

Band

C1.3

Transcripts

ENSMUST00000099646	ENSMUSP00000097238
ENSMUST00000023405	ENSMUSP00000023405
ENSMUST00000118438	ENSMUSP00000113127
ENSMUST00000149797	ENSMUSP00000123287

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0005543	phospholipid binding
GO:0019001	guanyl nucleotide binding
GO:0031683	G-protein beta/gamma-subunit complex binding
GO:0046872	metal ion binding

Biological Process

GO:0006471	protein ADP-ribosylation
GO:0006612	protein targeting to membrane
GO:0006886	intracellular protein transport
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0007265	Ras protein signal transduction
GO:0016055	Wnt signaling pathway
GO:0042384	cilium assembly
GO:0045444	fat cell differentiation
GO:0051258	protein polymerization

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005879	axonemal microtubule
GO:0005930	axoneme
GO:0016020	membrane
GO:0030117	membrane coat
GO:0034464	BBSome
GO:0060170	ciliary membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000113966

View Gene Order

ENSBTAG00000010091

Not yet available

Cross-References

SwissProt

O88848

TrEMBL

UniProt Splice Variant

Entrez Gene

56297

UniGene

Mm.392505

RefSeq

XM_006522398 NM_019665

OMIM

CCDS

CCDS28259

HPRD

IMGT

MGI ID

MGI:1927136

MGI Symbol

Arl6

EMBL

AF031903 AK003778 AK158832

GenPept

AAC62194 BAB22990 BAE34686

RNA Seq Atlas

56297