InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tpm3

Summary

InnateDB Protein

IDBP-401040.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tpm3

Protein Name

tropomyosin 3, gamma

Synonyms

gamma-TM; hTM30nm; hTMnm; TM30nm; Tm5NM; TMnm; Tpm-5; Tpm5; Trop-5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000113578

InnateDB Gene

IDBG-165882 (Tpm3)

Protein Structure

UniProt Annotation

Function

Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.

Subcellular Localization

Isoform 2: Cytoplasm, cytoskeleton.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	40 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding

Biological Process

Cellular Component

GO:0001725	stress fiber
GO:0002102	podosome
GO:0005737	cytoplasm
GO:0030426	growth cone
GO:0030863	cortical cytoskeleton
GO:0031941	filamentous actin
GO:0032154	cleavage furrow
GO:0043005	neuron projection