Version 5.4
| Mus musculus Gene: Tpm3 | |||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||
| InnateDB Gene | IDBG-165882.6 | ||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
| Gene Symbol | Tpm3 | ||||||||||||||||||||||
| Gene Name | tropomyosin 3, gamma | ||||||||||||||||||||||
| Synonyms | gamma-TM; hTM30nm; hTMnm; TM30nm; Tm5NM; TMnm; Tpm-5; Tpm5; Trop-5 | ||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000027940 | ||||||||||||||||||||||
| Encoded Proteins |
tropomyosin 3, gamma
tropomyosin 3, gamma
tropomyosin 3, gamma
tropomyosin 3, gamma
tropomyosin 3, gamma
tropomyosin 3, gamma
tropomyosin 3, gamma
tropomyosin 3, gamma
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143549:
This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Mutations in this gene result in autosomal dominant nemaline myopathy, and oncogenes formed by chromosomal translocations involving this locus are associated with cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] This gene encodes a member of the tropomyosin family of actin-binding proteins. Tropomyosins are dimers of coiled-coil proteins that provide stability to actin filaments and regulate access of other actin-binding proteins. Mutations in this gene result in autosomal dominant nemaline myopathy and other muscle disorders. This locus is involved in translocations with other loci, including anaplastic lymphoma receptor tyrosine kinase (ALK) and neurotrophic tyrosine kinase receptor type 1 (NTRK1), which result in the formation of fusion proteins that act as oncogenes. There are numerous pseudogenes for this gene on different chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013] |
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| Gene Information | |||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||
| Genomic Location | Chromosome 3:90072649-90100902 | ||||||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||||||
| Band | F1 | ||||||||||||||||||||||
| Transcripts | |||||||||||||||||||||||
| Interactions | |||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||
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Species
Homo sapiens
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Gene ID
Gene Order
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| Pathways | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME |
Striated Muscle Contraction pathway
Smooth Muscle Contraction pathway
Muscle contraction pathway
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| KEGG |
Thyroid cancer pathway
Cardiac muscle contraction pathway
Pathways in cancer pathway
Hypertrophic cardiomyopathy (HCM) pathway
Dilated cardiomyopathy pathway
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| INOH | |||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME |
Smooth Muscle Contraction pathway
Striated Muscle Contraction pathway
Muscle contraction pathway
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| KEGG |
Thyroid cancer pathway
Hypertrophic cardiomyopathy (HCM) pathway
Pathways in cancer pathway
Cardiac muscle contraction pathway
Dilated cardiomyopathy pathway
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| INOH | |||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||
| Cross-References | |||||||||||||||||||||||
| SwissProt | P21107 | ||||||||||||||||||||||
| TrEMBL | Q58E70 | ||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||
| Entrez Gene | 59069 | ||||||||||||||||||||||
| UniGene | Mm.240839 | ||||||||||||||||||||||
| RefSeq | NM_001253738 NM_001253740 NM_022314 XM_006501840 | ||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||
| CCDS | CCDS57223 CCDS38499 | ||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||
| MGI ID | MGI:1890149 | ||||||||||||||||||||||
| MGI Symbol | Tpm3 | ||||||||||||||||||||||
| EMBL | AF317223 AK088111 AK088902 AK145238 AK145243 AK145804 AK146349 AK146557 AK151441 AK151500 AK151578 AK151595 AK151602 AK152659 AK153031 AK160011 AK165428 AK166836 AK167268 AK167534 AK168843 AK169102 AK169245 AK169821 BC092045 U04541 X53753 X72633 | ||||||||||||||||||||||
| GenPept | AAA03725 AAG38596 AAH92045 BAC40150 BAC40643 BAE26319 BAE26321 BAE26659 BAE27101 BAE27258 BAE30403 BAE30451 BAE30518 BAE30535 BAE30542 BAE31395 BAE31663 BAE35558 BAE38183 BAE39058 BAE39381 BAE39603 BAE40666 BAE40884 BAE41009 BAE41391 CAA37782 CAA51209 | ||||||||||||||||||||||
| RNA Seq Atlas | 59069 | ||||||||||||||||||||||