InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Smarcb1

Summary

InnateDB Protein

IDBP-401067.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Smarcb1

Protein Name

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1

Synonyms

AU020204; Baf47; Ini1; Snf5; SNF5/INI1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000112463

InnateDB Gene

IDBG-164041 (Smarcb1)

Protein Structure

UniProt Annotation

Function

Core component of the BAF (SWI/SNF) complex. This ATP- dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron- specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post- mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. {ECO:0000250, ECO:0000269PubMed:17640523}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 127 interaction(s) predicted by orthology.

Experimentally validated
Total	30 [view]
Protein-Protein	29 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	127 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0030957	Tat protein binding

Biological Process

GO:0001824	blastocyst development
GO:0001835	blastocyst hatching
GO:0006281	DNA repair
GO:0006337	nucleosome disassembly
GO:0006338	chromatin remodeling
GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007399	nervous system development
GO:0008285	negative regulation of cell proliferation
GO:0030154	cell differentiation
GO:0039692	single stranded viral RNA replication via double stranded DNA intermediate
GO:0043044	ATP-dependent chromatin remodeling
GO:0043923	positive regulation by host of viral transcription
GO:0044772	mitotic cell cycle phase transition
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity

Cellular Component

GO:0000228	nuclear chromosome
GO:0001741	XY body
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0016514	SWI/SNF complex
GO:0071564	npBAF complex
GO:0071565	nBAF complex